Methodological constraints in interpreting serum paraoxonase-1 activity measurements: an example from a study in HIV-infected patients

Abstract Background Paraoxonase-1 (PON1) is an antioxidant enzyme that attenuates the production of the monocyte chemoattractant protein-1 (MCP-1) in vitro.Although oxidation and inflammation are closely related processes, the association between PON1 and MCP-1 has not been completely characterised due, probably, to that the current use of syntheti

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Mechanisms regulating the CRISPR-Cas systems

The CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats- CRISPR associated proteins) is a prokaryotic system that enables sequence specific recognition and cleavage of nucleic acids.This is possible due gumball bere to cooperation between CRISPR array which contains short fragments of DNA called spacers that are complimentary to t

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